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KMID : 1161420160190020133
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Journal of Medicinal Food
2016 Volume.19 No. 2 p.133 ~ p.140
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Purslane Extract and Glucose Homeostasis in Adults with Type 2 Diabetes: A Double-Blind, Placebo-Controlled Clinical Trial of Efficacy and Safety
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Wainstein Julio
Landau Zohar
Dayan Yosefa Bar
Jakubowicz Daniela
Grothe Torsten
Perrinjaquet-Moccetti Tania
Boaz Mona
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Abstract
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Purslane extract (PE) is derived from Portulaca oleracea L., a medicinal plant used in traditional medicine for its antidiabetic properties. This randomized, placebo-controlled clinical trial was designed to evaluate the efficacy and safety of PE in improving glucose control, blood pressure, and lipid profile in adults with type 2 diabetes mellitus (T2DM) treated with a single oral hypoglycemic agent at baseline. Subjects were randomized to treatment with three capsules of PE/day or a matched placebo. Change from baseline to the week 12 end-of-follow-up visit measures of glucose homeostasis, hemodynamics, and lipid profile was compared by treatment assignment. In addition, these measures were evaluated in a subgroup of “responders,” defined as patients whose week 12 HbA1c was lower than baseline values, regardless of treatment assignment. This group was further assessed in subgroups of baseline oral hypoglycemic treatment. A total of 63 participants were treated with either PE (n?=?31, 11 females, mean age 52.4?±?7.9 years) or matched placebo (n?=?32, 11 females, mean age 58.3?±?10.8 years). In the total cohort, systolic blood pressure declined significantly more in the PE group than the placebo group: ?7.5?±?5.0 versus ?0.01?±?0.3?mmHg, P?
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KEYWORD
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purslane, randomized clinical trial, type 2 diabetes
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